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Discovery of four plasmatic biomarkers potentially predicting cardiovascular outcome in peripheral artery disease

B M M Kremers1, J N Posma2, S Heitmeier3

  • 1Laboratory for Clinical Thrombosis and Hemostasis, Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Universiteitssingel 50, Room 4.330, 6229 ER, Maastricht, The Netherlands. b.kremers@student.maastrichtuniversity.nl.

Scientific Reports
|November 2, 2022
PubMed

Insights

New biomarkers like interleukin-6 (IL-6), protease-activated receptor 1 (PAR1), galectin-9 (Gal-9), and TNFRSF11A predict cardiovascular events and mortality in peripheral artery disease (PAD) patients.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Inflammation Research

Background:

  • Peripheral artery disease (PAD) patients face elevated cardiovascular risk, even with current treatments.
  • Existing risk stratification relies on known atherothrombotic pathways, potentially missing crucial unexplored mechanisms.
  • Novel biomarkers are needed for improved cardiovascular risk assessment in PAD.

Purpose of the Study:

  • To investigate the association between a comprehensive set of cardiovascular biomarkers and cardiovascular risk in PAD patients.
  • To identify novel predictive markers beyond traditional atherothrombotic pathways.
  • To explore underlying biological processes associated with cardiovascular events in PAD.

Main Methods:

  • An observational cohort study of 120 PAD outpatients followed for one year.
  • Assessment of a composite endpoint including myocardial infarction, revascularization, stroke, acute limb ischemia, and mortality.
  • Analysis of 184 biomarkers using proximity extension assay on plasma samples.

Main Results:

  • Fifteen patients experienced a composite endpoint event.
  • Elevated plasma levels of IL-6, PAR1, Gal-9, and TNFRSF11A were significantly associated with increased cardiovascular events and mortality.
  • Positive regulation of acute inflammatory responses and leukocyte chemotaxis were identified as key biological pathways.

Conclusions:

  • IL-6, PAR1, Gal-9, and TNFRSF11A are potent predictors of cardiovascular events and mortality in PAD.
  • These biomarkers may offer improved risk stratification for PAD patients.
  • The identified biomarkers represent potential targets for future drug development to mitigate cardiovascular risk.

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