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Serum and urinary carnosinase-1 correlate with kidney function and inflammation
Shiqi Zhang1, Di Cui2, Mingna Tang2
1Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. zhangshiqi@ahmu.edu.cn.
Amino Acids
|November 2, 2022
Summary
Serum and urinary carnosinase-1 (CN-1) levels are linked to kidney function decline in diabetic kidney disease (DKD). CN-1 expression also appears connected to inflammation in diabetes.
Area of Science:
- Nephrology
- Endocrinology
- Immunology
Background:
- Diabetic kidney disease (DKD) is a major complication of diabetes.
- The carnosinase dipeptidase 1 (CNDP1) gene is implicated in DKD susceptibility.
- Previous research suggests a protective (CTG)5 allele in Caucasians, but its role in Chinese populations is less clear.
Purpose of the Study:
- To investigate the association between serum and urinary carnosinase-1 (CN-1) concentrations and DKD progression.
- To determine the influence of CN-1 on diabetes-associated inflammation.
Main Methods:
- Cross-sectional study of 622 individuals (247 type 2 diabetes without DKD, 165 with DKD, 210 healthy controls).
- Uni- and multivariate regression analyses to identify predictors of urinary albumin creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), and CN-1 levels.
- Animal model (STZ-injected mice with skin wound) to assess CN-1 expression in inflammation.
Main Results:
- Serum CN-1 correlated positively with eGFR (p=0.001).
- Urinary CN-1 associated with eGFR and tubular injury markers (urinary cystatin C, urinary retinol-binding protein).
- Serum CN-1 showed positive correlation with inflammatory markers (neutrophils, lymphocytes).
- Diabetic mice with skin wounds exhibited increased liver and kidney CN-1 expression compared to controls.
Conclusions:
- Serum and urinary CN-1 levels are significantly associated with indicators of impaired renal function in diabetic patients.
- CN-1 expression may play a role in the inflammatory processes related to diabetes.
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