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Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer
Published on: July 18, 2017
Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications
Xinyang Zhong1,2, Xuefeng He1,2, Yaxian Wang1,2
1Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Abstract:
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression. As a hallmark of cancer, Warburg effect promotes cancer metastasis and remodels the tumor microenvironment, including promoting angiogenesis, immune suppression, cancer-associated fibroblasts formation and drug resistance. Targeting Warburg metabolism would be a promising method for the treatment of CRC. In this review, we summarize information about the roles of Warburg effect in tumor microenvironment to elucidate the mechanisms governing Warburg effect in CRC and to identify novel targets for therapy.
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