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Related Experiment Videos

Multiple thromboses in systemic lupus erythematosus.

S Appan, M L Boey, K W Lim

    Archives of Disease in Childhood
    |July 1, 1987
    PubMed
    Summary
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    A pediatric case of systemic lupus erythematosus presented with widespread blood clots. High-dose steroids effectively treated the condition, even without anticoagulant therapy.

    Area of Science:

    • Pediatric Rheumatology
    • Hematology
    • Immunology

    Background:

    • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect multiple organ systems.
    • Thrombosis is a known complication of SLE, particularly in adults, but less commonly reported in pediatric cases.
    • Lupus anticoagulant is an antiphospholipid antibody associated with an increased risk of thrombosis.

    Observation:

    • A 5-year-old female diagnosed with systemic lupus erythematosus presented with extensive thromboses at multiple sites.
    • Coagulation screening confirmed the presence of lupus anticoagulant in the patient.
    • The patient experienced a satisfactory recovery without the need for anticoagulant medications.

    Findings:

    • High-dose corticosteroid therapy was initiated for the patient's systemic lupus erythematosus.

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  • The thrombotic events resolved, and the patient showed significant clinical improvement.
  • The absence of anticoagulant treatment during recovery highlights a potential therapeutic approach.

    • Implications:

    • This case suggests that high-dose steroids may be sufficient to manage thrombotic complications in pediatric SLE patients with lupus anticoagulant.
    • It underscores the importance of considering thrombosis in children with SLE, even with atypical presentations.
    • Further research may explore the efficacy of steroid-sparing agents or alternative treatments in preventing thrombosis in pediatric lupus.