Fluorine in metal-catalyzed asymmetric transformations: the lightest halogen causing a massive effect
Samuel Lauzon1, Thierry Ollevier1
1Département de Chimie, Université Laval 1045 Avenue de la Médecine Québec QC G1V 0A6 Canada thierry.ollevier@chm.ulaval.ca.
Chemical Science
|November 2, 2022
Summary
This review covers significant applications of fluorine-containing ligands in catalysis from 2001-2021. It details metal-ligand interactions and structure-reactivity insights from these specialized chiral catalysts.
Area of Science:
- Organometallic Chemistry
- Catalysis
- Fluorine Chemistry
Background:
- Fluorine-containing ligands are crucial in modern catalysis.
- Their unique electronic properties influence metal-ligand interactions.
- Understanding these effects is key to designing efficient catalysts.
Purpose of the Study:
- To review significant applications of fluorine-containing ligands in catalysis.
- To classify ligands based on donor atoms.
- To highlight metal-ligand interactions and structure-reactivity relationships.
Main Methods:
- Literature review of research published from 2001 to mid-2021.
- Classification of ligands by donor atom type.
- Analysis of structure-reactivity relationships in fluorinated chiral catalysts.
Main Results:
- Comprehensive overview of diverse applications.
- Systematic classification of fluorine-containing ligands.
- Demonstration of fluorine's impact on catalyst performance and selectivity.
Conclusions:
- Fluorine-containing ligands offer significant advantages in catalysis.
- Their judicious design enables fine-tuning of metal-ligand interactions.
- Further exploration promises advancements in asymmetric synthesis and beyond.
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