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Updated: Aug 23, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Silver-catalyzed cascade cyclization and functionalization of N-aryl-4-pentenamides: an efficient route to
Zeguo Fang1,2, Lin Xie1, Liang Wang1
1Hubei Provincial Key Laboratory of Green Materials for Light Industry, Hubei University of Technology Wuhan 430068 China dongli@hbut.edu.cn.
Abstract:
The synthesis of γ-lactam-substituted quinone derivatives through a Ag2O-catalyzed cascade cyclization and functionalization of N-aryl-4-pentenamides has been developed. Related 2-oxazolidinone substituted quinone products can be also obtained with N-aryl allyl carbamates. The reactions proceed through an amidyl radical-initiated 5-exo-trig cyclization and followed radical addition to quinones. They provide an efficient route to various γ-lactam-substituted quinone derivatives with a wide range of substrate scope.
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