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Pulmonary Manifestations in Rheumatological Diseases
Gaurang M Aurangabadkar1, Milind Y Aurangabadkar2, Sumer S Choudhary1
1Respiratory Medicine, Datta Meghe Medical College, Datta Meghe Institute of Medical Sciences, Nagpur, IND.
Cureus
|November 2, 2022
Summary
This review explores pulmonary involvement in autoimmune disorders, focusing on rheumatoid arthritis, lupus, and systemic sclerosis. It details genetic insights, risk factors, and treatment for lung complications in these rheumatological conditions.
Area of Science:
- Rheumatology
- Pulmonology
- Genetics
Background:
- Autoimmune disorders frequently cause pulmonary complications, impacting patient care.
- Recent epidemiological and genetic research has enhanced understanding of lung involvement in rheumatological diseases.
- Key conditions include systemic lupus erythematosus (SLE), dermatomyositis/polymyositis, rheumatoid arthritis (RA), and systemic sclerosis (SSc).
Purpose of the Study:
- To provide a concise overview of pulmonary involvement in four common rheumatological conditions.
- To summarize clinical, epidemiological, and genetic aspects of these diseases.
- To highlight characteristic radiological patterns and treatment options for lung manifestations.
Main Methods:
- Review of recent epidemiological data (last 10-15 years).
- Analysis of advances in genetics related to autoimmune disease pathogenesis.
- Synthesis of clinical, radiological, and therapeutic information for SLE, dermatomyositis/polymyositis, RA, and SSc.
Main Results:
- Improved understanding of risk factors and pathophysiology of pulmonary involvement.
- Genetic insights offer a deeper understanding of disease mechanisms.
- Characteristic radiological findings and diverse treatment strategies are identified for each condition.
Conclusions:
- Pulmonary involvement is a significant concern in systemic lupus erythematosus, dermatomyositis/polymyositis, rheumatoid arthritis, and systemic sclerosis.
- Integrated approaches considering clinical, genetic, and radiological data are crucial for effective management.
- Further research into targeted therapies for lung manifestations is warranted.
Keywords:
bronchiectasisdermatomyositisinterstitial lung diseaselimited systemic sclerosispulmonary arterial hypertensionrheumatoid arthriitissystemic lupus erythematosusMore Related Videos
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