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Higenamine as a Potential Pharmacologic Stress Agent in the Detection of Coronary Artery Disease

Na-Na Zhang1, Zi-Jian Li2, Hai-Bo Zhu3

  • 1Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100050, China.

Chinese Medical Sciences Journal = Chung-Kuo I Hsueh K'O Hsueh Tsa Chih
|November 2, 2022
PubMed

Insights

Higenamine (HG) shows promise as a safe and effective stress agent for myocardial perfusion imaging (MPI) in detecting coronary artery disease (CAD). This review explores HG

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Pharmacology

Background:

  • Myocardial perfusion imaging (MPI) is crucial for diagnosing and managing coronary artery disease (CAD).
  • Current pharmacologic stress agents for MPI, like vasodilators and adrenergic agents, have limitations including contraindications and adverse effects.
  • There is a need for alternative stress agents suitable for a broader patient population.

Approach:

  • This review focuses on Higenamine (HG), a beta-adrenergic agonist.
  • It examines HG's potential as a stress agent in MPI for CAD detection.
  • The review covers HG's mechanism of action, stress protocols, efficacy, and safety.

Key Points:

  • Higenamine (HG) is being investigated as a stress agent for myocardial infarction and shows promise in MPI for CAD.
  • HG acts as a beta-adrenergic receptor agonist.
  • Preclinical and clinical studies suggest HG's value in MPI for CAD detection.

Conclusions:

  • Higenamine (HG) presents a potentially safer and more broadly applicable alternative stress agent for MPI.
  • Further research into HG's application in MPI for CAD is warranted.

Keywords:
coronary artery diseasehigenaminemyocardial perfusion imagingstress agent

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