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C-CAT: The National Datacenter for Cancer Genomic Medicine in Japan

Takashi Kohno1, Mamoru Kato1, Shinji Kohsaka1

  • 1Center for Cancer Genomics and Advanced Therapeutics (C-CAT), National Cancer Center, Tokyo, Japan.

Cancer Discovery
|November 2, 2022
PubMed

Insights

Japan

Area of Science:

  • Oncology
  • Genomics
  • Health Informatics

Background:

  • Japan launched national cancer genomic medicine (CGM) in June 2019.
  • A network of 233 CGM hospitals and the national Center for Cancer Genomics and Advanced Therapeutics (C-CAT) were established.
  • C-CAT serves as the national data center for CGM.

Purpose of the Study:

  • To describe the implementation and data infrastructure of Japan's national cancer genomic medicine program.
  • To highlight the role of C-CAT in collecting and reporting comprehensive genomic profiling (CGP) data.
  • To inform about the accessibility of aggregated clinical and genomic data for research and development.

Main Methods:

  • Comprehensive genomic profiling (CGP) tests are conducted for cancer patients.
  • Clinical information and genomic data are securely transferred to C-CAT.
  • C-CAT generates "C-CAT Findings" reports with clinical annotations and matched clinical trials.

Main Results:

  • As of June 30, 2022, C-CAT aggregated 36,340 clinical/genomic data points.
  • The number of aggregated data points is rapidly increasing.
  • Data is available for sharing with CGM hospitals, academic institutions, and industries.

Conclusions:

  • Japan's national CGM program, supported by C-CAT, is successfully accumulating valuable clinical and genomic data.
  • The centralized data repository facilitates precision medicine initiatives.
  • Open data sharing promotes further research and therapeutic advancements in oncology.
Abstract

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