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Targeted Wolfram-Doped Polypyrrole for Photonic Hyperthermia-Synergized Radiotherapy.

Yin Wang1, Weiwei Zeng2, Huazhen Liang3

  • 1Department of Radiation Oncology, Nanfang Hospital Southern Medical University, Guangzhou 510515, China.

ACS Applied Materials & Interfaces
|November 2, 2022
PubMed
Summary

Novel wolfram-doped polypyrrole (WPPy) nanoparticles enhance radiotherapy by combining photothermal therapy and radiosensitization. WPPy@SP94 shows high tumor accumulation and effectively inhibits growth with minimal side effects.

Keywords:
ROS generationactive targetingpolypyrroleradiosensitizationradiotherapy

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Single ionizing radiation therapy (RT) is limited by insufficient tumor elimination and normal tissue damage.
  • Polypyrrole (PPy) lacks inherent radiosensitizing properties for effective cancer treatment.

Purpose of the Study:

  • To develop novel wolfram-doped polypyrrole (WPPy) nanoparticles as a radiosensitizer and photothermal agent.
  • To enhance WPPy@SP94 tumor targeting and therapeutic efficacy in combination with radiotherapy and hyperthermia.

Main Methods:

  • Fabrication of WPPy via oxidative polymerization using WCl6 as a catalyst.
  • Decoration of WPPy with SP94 polypeptide for targeted delivery.
  • Evaluation of WPPy@SP94 biocompatibility, photothermal conversion, radiosensitivity, and anti-tumor effects in vitro and in vivo.

Main Results:

  • WPPy@SP94 exhibited excellent biocompatibility, high photothermal conversion, and enhanced radiosensitivity.
  • WPPy@SP94 demonstrated significant tumor accumulation, induced DNA damage, and ROS generation under X-ray irradiation.
  • Combined photothermal hyperthermia and radiotherapy with WPPy@SP94 effectively inhibited tumor growth with negligible adverse effects.

Conclusions:

  • Wolfram-doped polypyrrole (WPPy@SP94) serves as an effective radiosensitizer and photothermal agent for cancer therapy.
  • WPPy@SP94 offers a promising strategy for synergistic hyperthermia-radiotherapy with improved tumor targeting and reduced toxicity.
  • This study expands polypyrrole synthesis and presents WPPy@SP94 as a potential agent for cancer radiotherapy.