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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Cadherins in Tissue Organization01:19

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The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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Mitogens and the Cell Cycle

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Related Experiment Video

Updated: Aug 23, 2025

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

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Neuroepithelial Interactions in Cancer.

Gustavo Ayala1

  • 1Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, McGovern School of Medicine, Houston, Texas, USA;

Annual Review of Pathology
|November 2, 2022
PubMed
Summary

Cancer development mirrors normal tissue

Area of Science:

  • Oncology
  • Neuroscience
  • Cell Biology

Background:

  • Nerves regulate epithelial cell homeostasis and metabolism.
  • Cancer development involves recapitulating neural regulation of epithelial tissues.
  • Denervation of organs inhibits tumorigenesis.

Purpose of the Study:

  • To elucidate the intricate relationship between neural regulation and cancer progression.
  • To explore the stages of neuro-epithelial interactions during tumorigenesis.
  • To highlight the necessity of incorporating neural biology into cancer treatment strategies.

Main Methods:

  • Review of existing literature on neurobiology and cancer.
  • Analysis of the stages of cancer development in relation to neural involvement.
Keywords:
axonogenesiscancernervesneurogenesisneuronalperineuraltransdifferentiation

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In Vitro Modeling of Cancerous Neural Invasion: The Dorsal Root Ganglion Model
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In Vitro Modeling of Cancerous Neural Invasion: The Dorsal Root Ganglion Model

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An Enzyme- and Serum-free Neural Stem Cell Culture Model for EMT Investigation Suited for Drug Discovery
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  • Examination of perineural invasion and cancer cell transdifferentiation.

    • Main Results:

    • Cancer cells hijack neural regulation pathways for growth.
    • Tumorigenesis is influenced by the presence or absence of nerves.
    • Key stages include axonogenesis, neurogenesis, perineural invasion, and cell transdifferentiation.
    • Perineural invasion enhances cancer cell proliferation and reduces apoptosis.

    Conclusions:

    • Cancer progression is intrinsically linked to neural regulation.
    • Effective cancer treatments must address the neuro-epithelial interactions.
    • Understanding these interactions is crucial for developing novel therapeutic approaches.