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Human pre-60S assembly factors link rRNA transcription to pre-rRNA processing

Mason A McCool1, Amber F Buhagiar1, Carson J Bryant1

  • 1Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

RNA (New York, N.Y.)
|November 2, 2022
PubMed
Summary

The nucleolar proteins RSL24D1 and the PeBoW complex are crucial for ribosome biogenesis. This study reveals their unexpected role in regulating pre-ribosomal RNA transcription, impacting protein synthesis and cell stability.

Keywords:
60S large ribosomal subunitnucleoluspre-rRNA processingrRNA transcriptionribosome biogenesis

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