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Complex sweat gland hamartoma: A case report.

Zachary Skopec¹, Kristen G Berrebi¹, Mary Stone^1,2

¹Department of Dermatology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Journal of Cutaneous Pathology

|November 3, 2022

Summary

This study details a rare complex sweat gland hamartoma in a child, featuring syringocystadenoma papilliferum, tubular apocrine adenoma, and eccrine nevus. Such combined tumors are exceptionally uncommon, presenting unique diagnostic challenges.

Keywords:

Syringocystadenoma papilliferum eccrine glands eccrine nevus skin neoplasms sweat gland neoplasms tubular apocrine adenoma

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Area of Science:

Dermatopathology
Histopathology
Oncology

Background:

Syringocystadenoma papilliferum (SCAP), tubular apocrine adenoma (TAA), and eccrine nevus are rare benign sweat gland tumors.
SCAP and TAA are often associated with nevus sebaceus, but rarely co-occur within the same lesion.
Eccrine nevus is less common and seldom linked with other benign adnexal lesions.

Observation:

A 7-year-old female presented with a complex sweat gland hamartoma.
The lesion exhibited histomorphologic features of SCAP, TAA, and eccrine nevus.
This represents an unusual co-occurrence of these three distinct entities.

Findings:

The case highlights a complex sweat gland hamartoma with a unique combination of SCAP, TAA, and eccrine nevus.
Histopathological analysis confirmed the presence of all three tumor types within a single lesion.
This finding is rare, particularly the co-occurrence of eccrine nevus with SCAP and TAA.

Implications:

This case expands the understanding of rare sweat gland tumors and their potential combinations.
It underscores the importance of thorough histopathological examination for accurate diagnosis of complex adnexal lesions.
Further research may elucidate the developmental pathways and associations of such complex hamartomas.