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Secure secondary utilization system of genomic data using quantum secure cloud.

Mikio Fujiwara1, Hiroki Hashimoto2, Kazuaki Doi3

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A new quantum-secure cloud system enables secure storage and analysis of human genome data. This distributed secure genomic data analysis system (DSGD) supports diverse hardware and offers comparable performance with or without encryption.

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Area of Science:

  • Genomics and Bioinformatics
  • Cybersecurity and Quantum Technology

Background:

  • Secure storage and secondary use of human genome data are critical for advancing genome research and personalized medicine.
  • Whole genome sequencing data (FASTQ) is essential for detecting mutations in hereditary diseases and cancer, but current secure data analysis methods are limited by algorithm compatibility and computational costs.
  • Bioinformatics tools for FASTQ data analysis are continuously evolving, necessitating adaptable secure analysis platforms.

Purpose of the Study:

  • To develop a high-performance, one-stop system for large-scale genome data analysis with secure secondary data use.
  • To enable data owners and multiple users with varying access levels to securely utilize genomic data.
  • To create a quantum-secure cloud system capable of handling diverse analytical hardware and software.

Main Methods:

  • Development of a distributed secure genomic data analysis system (DSGD) utilizing a trusted server.
  • Implementation of a quantum-secure cloud infrastructure based on the Tokyo QKD Network for information-theoretic security.
  • Integration of versatile hardware support (GPUs, FPGAs, CPUs) within the trusted server for flexible bioinformatics tool deployment.

Main Results:

  • The DSGD system provides a secure platform for genome data analysis with granular access control.
  • The system demonstrated comparable data processing throughput with and without encryption on the trusted server.
  • The trusted server effectively supports a variety of sequencing analysis hardware and software.

Conclusions:

  • The developed quantum-secure cloud system offers a robust solution for secure large-scale genome data analysis.
  • DSGD is ready for deployment in research institutes and hospitals performing daily whole genome sequencing diagnostics.
  • The system addresses the limitations of existing secure data analysis methods by offering broad algorithm and hardware compatibility.