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Gastrocolonic Response.

Lev Dorfman1, Khalil El-Chammas2,3, Sherief Mansi2,3

  • 1Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA. levdorfman@gmail.com.

Current Gastroenterology Reports
|November 3, 2022
PubMed
Summary
This summary is machine-generated.

The gastrocolonic response (GCR) is a normal colon activity increase after eating, mediated by nerves. Abnormal GCR indicates underlying issues and can be a treatment target.

Keywords:
Gastro colonic responsecolonic manometryconstipationgastrocolonic reflexirritable bowel syndrome

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Area of Science:

  • Gastroenterology
  • Physiology
  • Colonic Motility

Background:

  • The gastrocolonic response (GCR) is a physiological increase in colon motor activity post-meal.
  • Triggers include gastric dilation, calories, and meal fat.
  • Vagal nerve and neurohumoral pathways mediate GCR, influenced by pharmacology.

Purpose of the Study:

  • Review the physiologic basis of GCR.
  • Discuss clinical and diagnostic features of GCR.
  • Explore GCR implementation in pathological conditions.

Main Methods:

  • Assessment of GCR is integral to high-resolution colonic manometry.
  • Studies in patients with suspected colonic dysmotility.

Main Results:

  • GCR plays a role in constipation, diabetes, dumping syndrome, and IBS.
  • Novel sensory triggers for GCR have been identified.
  • Abnormal GCR signifies underlying pathology and potential treatment targets.

Conclusions:

  • GCR is a key physiological response evaluated via colonic manometry.
  • Understanding GCR aids in diagnosing and managing colonic dysmotility.