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COVID-19 and Acute Coronary Syndrome: A Literature Review

Abidemi O Akinrinmade1,2, Vivien O Obitulata-Ugwu3, Nkechi B Obijiofor4

  • 1Medicine and Surgery, Benjamin S. Carson School of Medicine, Babcock University, Ilishan-Remo, NGA.

Cureus
|November 3, 2022
PubMed

Insights

The COVID-19 pandemic has been linked to acute coronary syndrome (ACS), a serious heart condition. Further research is needed to understand the direct relationship between COVID-19 and ACS for improved patient outcomes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • The COVID-19 pandemic has caused widespread health and socioeconomic disruptions globally.
  • Acute Coronary Syndrome (ACS) is a significant cardiovascular disease associated with high morbidity and mortality.
  • Increased reports of ACS have been observed in patients diagnosed with COVID-19.

Purpose of the Study:

  • To review the potential associations between COVID-19 and ACS.
  • To explore the pathophysiology of ACS in the context of COVID-19 infection.
  • To examine the pandemic's impact on ACS diagnosis and management.

Main Methods:

  • Literature review utilizing databases such as PubMed, ScienceDirect, WHO, and AHA.
  • Exploration of viral entry and replication mechanisms via angiotensin-converting enzyme II.
  • Discussion of hospital admission trends, diagnostic challenges, and treatment modifications for ACS during the pandemic.

Main Results:

  • COVID-19 infection is frequently reported in ACS patients.
  • The angiotensin-converting enzyme II pathway is implicated in viral entry and replication.
  • The pandemic has influenced ACS patient care pathways and highlighted potential vaccine-related cardiovascular concerns.

Conclusions:

  • A direct causal link between COVID-19 and ACS requires further investigation.
  • Understanding the association may pave the way for novel research and therapeutic strategies for ACS.
  • Continued research is crucial to elucidate the complex interplay between viral infections and cardiovascular events.

Keywords:
acute coronary syndromecovid-19non–st-segment elevation myocardial infarctionsars-cov-2st-segment elevation myocardial infarction

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