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Inverted Papilloma of the Middle Ear: Two New Cases and Systematic Review
Peter L Miller1, Erika Walsh1, Do-Yeon Cho1,2
1Department of Otolaryngology Head and Neck Surgery, University of Alabama Birmingham, Birmingham AL, USA.
Allergy & Rhinology (Providence, R.I.)
|November 3, 2022
Summary
Middle ear inverted papillomas are rare but frequently recur and transform into cancer. Complete surgical removal and close monitoring are essential for managing these challenging tumors.
Area of Science:
- Otolaryngology
- Surgical Pathology
- Oncology
Background:
- Inverted papillomas of the middle ear are exceptionally rare neoplasms.
- These tumors present a significant risk for recurrence and malignant transformation.
- Current literature reports 59 cases of middle ear inverted papillomas.
Purpose of the Study:
- To systematically review outcomes for middle ear inverted papillomas.
- To analyze demographics, anatomical locations, and HPV status.
- To evaluate malignant transformation and recurrence rates.
Main Methods:
- A systematic review was conducted using PubMed, Embase, Scopus, and Google Scholar.
- Searched databases for relevant articles up to June 25, 2020.
- Included 66 full-text articles after eliminating duplicates and irrelevant studies.
Main Results:
- Identified 31 primary and 26 secondary middle ear inverted papillomas.
- Malignant transformation rate was 34.4%.
- Recurrence rate was 53.6%.
Conclusions:
- Middle ear inverted papillomas necessitate complete surgical resection.
- Adjuvant radiation may be considered for recurrent or malignant cases.
- Frequent clinical follow-up is critical due to high recurrence and malignant transformation risks.
