Related Experiment Video

Updated: Aug 23, 2025

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.1K

Relationship between CYP2C19 Polymorphism and Clopidogrel Resistance in Patients with Coronary Heart Disease and

Rong Chang1,2, Wenqin Zhou3, Yi Ye3

  • 1Department of Cardiology, Shenzhen Longhua District Central Hospital, Shenzhen, China.

Genetics Research
|November 3, 2022
PubMed

Insights

CYP2C19 gene variations do not predict clopidogrel resistance in Han and Tibetan patients in Qinghai. Instead, age, activated partial thromboplastin time, and aspirin resistance are key risk factors for clopidogrel resistance.

Area of Science:

  • Pharmacogenomics
  • Cardiovascular Medicine
  • Internal Medicine

Background:

  • Clopidogrel is crucial for preventing ischemic events in cardiovascular diseases.
  • Clopidogrel resistance (CR) affects treatment efficacy.
  • CYP2C19 gene polymorphisms are ethnic and geographically variable, influencing CR.

Purpose of the Study:

  • To investigate the association between CYP2C19 polymorphisms and clopidogrel resistance (CR).
  • To analyze CR in Han and Tibetan populations with coronary heart disease and ischemic stroke in Qinghai Province, China.

Main Methods:

  • Whole exome sequencing was used to identify CYP2C19 polymorphisms (CYP2C19*2, *3, *17).
  • Patients diagnosed with coronary heart disease or cerebral infarction were enrolled.
  • Comparison of CR and non-CR groups was performed for genetic and clinical factors.

Main Results:

  • No significant association was found between CYP2C19 genotypes (*2, *3, *17) and CR in either Han or Tibetan populations.
  • In the Han population, age, activated partial thromboplastin time (APTT), and aspirin resistance were significantly correlated with CR.
  • No significant differences in indicators were observed between CR and non-CR groups in the Tibetan population.

Conclusions:

  • CYP2C19 alleles (*2, *3, *17) are not correlated with clopidogrel resistance in the studied populations.
  • Age, APTT, and aspirin resistance are identified as independent risk factors for CR in this region.
  • Findings highlight the need to consider non-genetic factors for CR management in Qinghai.
Abstract

More Related Videos

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control05:41

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

Published on: December 16, 2022

3.6K
Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy07:40

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Published on: May 26, 2023

1.3K

Related Concept Videos

Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
23
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
609
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
278
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.6K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
115
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.1K