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Vitiligo and systemic sclerosis: Are they associated?- Lessons from a population-based study.
Khalaf Kridin1,2,3, Keren Lyakhovitsky2, Dana Tzur-Bitan4,5
1Unit of Dermatology and Skin Research Laboratory, Baruch Padeh Medical Center, Poriya, Israel.
The Australasian Journal of Dermatology
|November 3, 2022
Summary
Vitiligo and systemic sclerosis (SSc) are bidirectionally linked. Patients with vitiligo have a higher risk of developing SSc, and SSc patients are more prone to vitiligo.
Area of Science:
- Dermatology and Immunology
- Epidemiology
- Rheumatology
Background:
- The epidemiological link between vitiligo and systemic sclerosis (SSc) requires precise evaluation.
- Understanding this association is crucial for patient management and risk assessment.
Purpose of the Study:
- To investigate the bidirectional association between vitiligo and systemic sclerosis (SSc).
Main Methods:
- A population-based study compared 20,851 vitiligo patients with 102,475 controls.
- Incidence and prevalence of SSc in vitiligo patients were assessed.
- Cox and logistic regression analyses calculated adjusted hazard and odds ratios.
Main Results:
- Vitiligo patients showed a significantly increased risk of developing SSc (HR, 5.37).
- A history of SSc was associated with elevated odds of developing vitiligo (OR, 2.09).
- Vitiligo patients with SSc were older and had higher rates of cardiovascular and metabolic comorbidities.
Conclusions:
- A robust bidirectional association exists between vitiligo and SSc.
- Physicians should be aware of this link when managing patients with either condition.
- Consider monitoring vitiligo patients with SSc for cardiovascular and metabolic issues.
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