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Left atrial phasic volumes and functions changes in asymptomatic patients with sarcoidosis: evaluation by

Hatice Solmaz1, Oner Ozdogan1

  • 1Department of Cardiology, University of Health Sciences, Tepecik Training and Research Hospital, Izmir, Turkey.

Acta Cardiologica
|November 3, 2022
PubMed

Insights

Three-dimensional echocardiography reveals subtle left atrial (LA) changes in asymptomatic sarcoidosis patients. These LA volume and function metrics may detect early subclinical cardiac involvement before symptoms appear.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Pulmonology

Background:

  • Cardiac involvement is a primary cause of mortality in sarcoidosis.
  • Many sarcoidosis patients are asymptomatic until advanced cardiac stages.
  • Early detection of cardiac involvement is crucial for timely intervention.

Purpose of the Study:

  • To investigate left atrial (LA) phasic volume and function changes using 3D echocardiography in asymptomatic sarcoidosis patients.
  • To assess the correlation of 3D echocardiography findings with cardiac magnetic resonance imaging.
  • To identify potential early biomarkers of subclinical cardiac involvement.

Main Methods:

  • A cross-sectional study involving 44 asymptomatic sarcoidosis patients and 40 healthy controls.
  • Utilized both 2D and 3D echocardiography, including tissue Doppler imaging.
  • Calculated LA active, passive, and total emptying fractions (EF) from 3D-derived LA phasic volumes.

Main Results:

  • While left ventricular ejection fraction (LVEF) was normal, sarcoidosis patients showed significantly higher LA diameters and E/e' ratios.
  • Sarcoidosis patients exhibited significantly lower A-wave and e' annular velocities.
  • 3D echocardiography revealed significantly higher LA minimum volume indices (LAVImin) and lower LA active (AAEF) and total emptying fractions (TAEF) in sarcoidosis patients compared to controls.

Conclusions:

  • 3D echocardiography-derived LA phasic volumes, including LAVImin, AAEF, and TAEF, show potential as indicators of subclinical cardiac involvement in asymptomatic sarcoidosis.
  • These quantitative measures may aid in the early identification of cardiac disease in sarcoidosis.
  • Further research can validate these findings and integrate them into clinical practice.
Abstract

Keywords:
3D-echocardiographyCardiac involvementleft atrial functionsleft atrial phasic volumessarcoidosis

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