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Paraoxonase-1 and fetuin-A levels in children with cerebral palsy
Özlem Unay Demirel1, Özlem Güngör2, Seyda İğnak Tarlığ3
1Department of Medical Biochemistry and Bahçeşehir University Göztepe Medical Park Hospital Central Laboratory, Faculty of Medicine, Bahçeşehir University, İstanbul, Turkey.
Insights
Paraoxonase-1 (PON-1) activity may aid in the early diagnosis of cerebral palsy (CP) in infants with risk factors. This study found significant differences in PON-1 levels between children with CP and controls.
Area of Science:
- Biochemistry
- Pediatrics
- Neurology
Background:
- Cerebral palsy (CP) research often focuses on risk factors and clinical status.
- Anti-inflammatory markers show potential for early CP diagnosis and classification.
- Fetuin-A and Paraoxonase-1 (PON-1) have not been previously studied in pediatric CP patients.
Purpose of the Study:
- To investigate the relationship between anti-inflammatory marker levels and clinical status in children with CP.
- To evaluate Fetuin-A and PON-1 as potential biomarkers in pediatric CP.
Main Methods:
- A study involving 79 children, divided into CP and control groups.
- Assessment of gross motor function and spasticity.
- Biochemical analysis of anti-inflammatory markers.
Main Results:
- Significant differences observed in PON-1 activity, high-sensitivity C-Reactive Protein, HDL, and total cholesterol between CP and control groups.
- No statistically significant difference found in Fetuin-A levels between the groups.
Conclusions:
- PON-1 activity determination can support early diagnosis in infants under 24 months with suspected CP and risk factors.
- PON-1 shows promise as a biomarker for early cerebral palsy detection.
Background:
Studies mostly focused on risk factors and clinical status in children with cerebral palsy (CP). Various antiinflammatory markers may help us in the early diagnosis and clinical classification of cerebral palsy patients. In this study, the relationship between antiinflammatory marker levels and clinical status in patients with CP is determined. It is the first time that Fetuin-A and Paraoxonase-1 (PON-1) are examined in children with CP.
Methods:
The study is conducted on 79 children which are divided into two groups as CP and control. Gross motor function and spasticity are evaluated in addition to biochemical parameters.
Results:
There is a statistically significant difference between CP and control group in terms of PON-1 activity, high sensitive C-Reactive Protein, HDL, and total cholesterol levels. There is no statistically significant difference in Fetuin A levels between the two groups.
Discussion:
In suspected CP patients less than 24 months of age who possess prenatal and postnatal risk factors, the determination of PON-1 activity can be considered as a biomarker to support early diagnosis.
