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Assessment of Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios in patients with acromegaly
İbrahim Etem Çelik1, Sevde Nur Fırat2, Uğur Bozkurt1
1Department of Cardiology, Ankara Education and Research Hospital, University of Health Sciences Turkey, Ankara, Turkey.
Insights
Patients with acromegaly exhibit prolonged ventricular repolarization, indicated by elevated Tp-e interval and Tp-e/QT ratios. These findings may aid in screening for dangerous arrhythmias in acromegaly patients.
Area of Science:
- Cardiology
- Endocrinology
- Electrophysiology
Background:
- Acromegaly is linked to cardiovascular complications, primarily ventricular arrhythmias due to abnormal ventricular repolarization.
- These complications represent a significant cause of mortality and morbidity in acromegaly patients.
Purpose of the Study:
- To investigate ventricular repolarization in acromegaly patients.
- To compare Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios between acromegaly patients and healthy controls.
Main Methods:
- Electrocardiographic analysis of 29 acromegaly patients and 30 healthy controls.
- Calculation of Tp-e interval, QT interval, corrected QT (QTc), Tp-e/QT, and Tp-e/QTc ratios.
Main Results:
- Significantly higher Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were observed in acromegaly patients compared to controls (p < 0.001, p = 0.019, p = 0.003, respectively).
- A positive correlation was found between left atrial volume index (LAVI) and Tp-e interval (r = 0.272, p = 0.039).
Conclusions:
- This study is the first to demonstrate elevated Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios in acromegaly.
- These repolarization abnormalities may serve as a biomarker for identifying patients at risk of malignant arrhythmias.
Background:
Cardiovascular complications, including ventricular arrhythmias associated with abnormalities of ventricular repolarization, are the leading cause of morbidity and mortality in patients with acromegaly. Herein, we aimed to investigate ventricular repolarization using Tp-e interval, Tp-e interval/QT, and Tp-e interval/QTc ratios in acromegalic patients compared to healthy subjects.
Methods:
A total of 29 patients (aged 51.9 ± 11.2, 65.5% women) with acromegaly and 30 control subjects (aged 47.3 ± 14.4, 63.3% women) were enrolled in the study. Tp-e and QT interval, corrected QT (QTc), Tp-e/QT, and Tp-e/QTc ratios were calculated from the 12-lead electrocardiogram.
Results:
Tp-e interval (89.28 ± 12.16 vs. 75.97 ± 9.92 ms; p < 0.001), Tp-e/QT ratio (0.237 ± 0.045 vs. 0.212 ± 0.029; p = 0.019), and Tp-e/ QTc ratio (0.218 ± 0.031 vs. 0.195 ± 0.026; p = 0.003) were significantly higher in patients with acromegaly compared to control group. A positive correlation was determined between left atrial volume index (LAVI) and Tp-e interval (r = 0.272, p = 0.039).
Discussion:
The current study is the first to have shown significantly increased Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio were increased in acromegalic patients. These results may be important for screening malignant arrhythmic events in acromegaly.
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