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Updated: Sep 29, 2026
07:06
Pentylenetetrazole-Induced Kindling Mouse Model
Published on: June 12, 2018
Changes in seizure susceptibility in rats following chronic administration of pentylenetetrazol
Biomedica Biochimica Acta
|January 1, 1987
Abstract:
Repeated administration of pentylenetetrazol (PTZ) once every 48 h in behaviourally active threshold and suprathreshold doses induces a marked enhancement of seizure behaviour (kindling phenomenon). In contrast, PTZ in initially subconvulsive doses failed to elicit convulsions more complex than stage 1 seizures. With 40 mg/kg PTZ i.p. kindled rats show in the fully kindled state a marked shift of the dose-response curve for PTZ-seizures to the left. The mean stage 4 dose of PTZ is 40 mg/kg in kindled and 75 mg/kg in non-kindled rats.
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