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Estimation of vaccine effectiveness using the screening method
1PHLS Communicable Disease Surveillance Centre, 61 Colindale Avenue, London NW9 5EQ, UK.
Abstract:
The screening method provides a simple and rapid way of estimating vaccine effectiveness. This paper discusses the validity of the screening method with particular reference to bias and precision. Methods for correcting confounding, adjusting for covariates and over-dispersion, and deriving confidence limits are discussed in a modelling framework. The methods are illustrated using data on measles and pertussis vaccines.
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