Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Sensitivity, Specificity, and Predicted Value

Sensitivity, Specificity, and Predicted Value

In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Is it appropriate to use fixed assay cut-offs for estimating seroprevalence?

Epidemiology and infection·2015

Same author

Use of the self-controlled case-series method in vaccine safety studies: review and recommendations for best practice.

Epidemiology and infection·2011

Same author

Epidemiological studies of the non-specific effects of vaccines: II--methodological issues in the design and analysis of cohort studies.

Tropical medicine & international health : TM & IH·2009

Same author

Measures of disassortativeness and their application to directly transmitted infections.

Biometrical journal. Biometrische Zeitschrift·2009

Same author

Hepatitis B vaccination and first central nervous system demyelinating events: reanalysis of a case-control study using the self-controlled case series method.

Vaccine·2007

Same author

Matrix models for childhood infections: a Bayesian approach with applications to rubella and mumps.

Epidemiology and infection·2005

Search research articles

Related Experiment Video

Updated: Aug 23, 2025

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

Estimation of vaccine effectiveness using the screening method.

C P Farrington¹

¹PHLS Communicable Disease Surveillance Centre, 61 Colindale Avenue, London NW9 5EQ, UK.

International Journal of Epidemiology

|November 3, 2022

Summary

This study validates a screening method for estimating vaccine effectiveness, offering a rapid approach. It details statistical techniques to ensure accurate and precise vaccine efficacy assessments.

Area of Science:

Epidemiology
Biostatistics
Vaccinology

Background:

Estimating vaccine effectiveness (VE) is crucial for public health.
Traditional methods can be time-consuming and complex.
A simple and rapid screening method for VE estimation is needed.

Purpose of the Study:

To evaluate the validity of a screening method for estimating vaccine effectiveness.
To examine sources of bias and assess the precision of the screening method.
To present a modeling framework for correcting confounding and other statistical challenges.

Main Methods:

The study discusses the validity of a screening method for vaccine effectiveness estimation.
Statistical methods for bias correction, precision assessment, and covariate adjustment are detailed.

More Related Videos

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Published on: June 19, 2018

Related Experiment Videos

Last Updated: Aug 23, 2025

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Published on: June 19, 2018

A modeling framework is used to address confounding and over-dispersion.

Main Results:

The screening method offers a simple and rapid approach to estimating vaccine effectiveness.
The paper provides methods for correcting confounding and adjusting for covariates.
Confidence limits can be derived within the proposed modeling framework.

Conclusions:

The screening method is a valid and efficient tool for estimating vaccine effectiveness.
The presented statistical framework enhances the reliability of VE estimates.
This approach is applicable to various vaccines, including measles and pertussis vaccines.