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    Global vaccination coverage for essential vaccines like DTPcv3 and MCV1 has declined to its lowest levels since 2008. This trend, exacerbated by the COVID-19 pandemic, leaves millions of infants unprotected against preventable diseases.

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    Area of Science:

    • Public Health
    • Epidemiology
    • Global Health Policy

    Background:

    • The Immunization Agenda 2030 aims to reduce morbidity and mortality from vaccine-preventable diseases.
    • Routine immunization services have faced significant disruptions globally due to the COVID-19 pandemic.

    Purpose of the Study:

    • To update global, regional, and national vaccination coverage estimates and trends through 2021.
    • To assess the impact of recent global events on immunization coverage rates.

    Main Methods:

    • Analysis of global, regional, and national vaccination coverage data up to 2021.
    • Comparison of current coverage rates with historical data (2015-2019, 2020).

    Main Results:

    • Global DTPcv3 coverage dropped to 81% in 2021, with 25 million infants unvaccinated, an increase from previous years.
    • MCV1 coverage also fell to 81% in 2021, the lowest since 2008.
    • Coverage decreased for BCG, Hib, HepB, Pol, and RCV vaccines, indicating widespread declines in routine immunization.

    Conclusions:

    • The COVID-19 pandemic has severely disrupted routine immunization services worldwide.
    • Urgent, context-specific strategies are needed to close immunization gaps and strengthen programs.
    • Catch-up vaccination and prioritization of essential services are crucial to prevent outbreaks.