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Updated: Aug 23, 2025

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
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MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

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68 Ga-PSMA-11 PET/CT and PET/MRI in Rectal Linitis Plastica Secondary to Prostate Adenocarcinoma

Qian Zhao1, Hui Dong2, Aisheng Dong3

  • 1From the Department of Nuclear Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia.

Clinical Nuclear Medicine
|November 3, 2022
PubMed

Insights

Rectal linitis plastica, a rare condition, can be the initial sign of prostate cancer. Imaging like MRI and PET/CT reveals characteristic rectal wall thickening and intense PSMA uptake.

Area of Science:

  • Oncology
  • Radiology
  • Nuclear Medicine

Background:

  • Rectal linitis plastica is an uncommon condition, often presenting as a diagnostic challenge.
  • Prostate adenocarcinoma can rarely manifest initially with rectal involvement.

Observation:

  • This case highlights rectal linitis plastica as the sole presenting manifestation of prostate adenocarcinoma.
  • The rectum was identified as the only metastatic site in this patient.

Findings:

  • Magnetic Resonance Imaging (MRI) demonstrated circumferential rectal wall thickening with a concentric ring pattern.
  • Positron Emission Tomography/Computed Tomography (PET/CT) and PET/MRI showed diffuse, intense uptake of 68 Ga-PSMA-11 in the affected rectal wall.

Implications:

  • Recognizing these specific imaging features is crucial for the early diagnosis of prostate adenocarcinoma presenting as rectal linitis plastica.
  • This case underscores the importance of comprehensive imaging in identifying rare metastatic patterns of prostate cancer.

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