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The miR-17-92 cluster: Yin and Yang in human cancers

Wenyuan Zhao1, Ananya Gupta2, Janusz Krawczyk3

  • 1Discipline of Pathology, Cancer Progression and Treatment Research Group, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland.

Cancer Treatment and Research Communications
|November 3, 2022
PubMed

Insights

The miR-17-92 cluster, a microRNA (miRNA) regulator, shows dual roles in cancer, acting as both an oncogene and tumor suppressor. Understanding its context-dependent functions is key for developing novel cancer biomarkers and therapeutics.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression involved in critical cellular processes.
  • Dysregulated miRNA expression is linked to human cancer development and progression.
  • The miR-17-92 cluster is a well-studied miRNA group with reported oncogenic and tumor-suppressive roles.

Purpose of the Study:

  • To review the recent advancements and context-dependent roles of the miR-17-92 cluster in various cancers.
  • To summarize mechanisms regulating miR-17-92 expression and its downstream molecular pathways.
  • To discuss its dual role as an oncogene and tumor suppressor, impacting cancer hallmarks.

Main Methods:

  • Literature review of recent progress on miR-17-92 cluster in cancer.
  • Analysis of regulatory mechanisms and molecular pathways controlled by miR-17-92.
  • Discussion of cellular context-dependent effects and targeting strategies.

Main Results:

  • The miR-17-92 cluster exhibits context-dependent oncogenic or tumor-suppressive functions in different cancers.
  • Its expression is tightly regulated, and it impacts key cancer hallmarks through various targets.
  • Cellular context significantly influences the biological effects of the miR-17-92 cluster.

Conclusions:

  • The miR-17-92 cluster's paradoxical roles in cancer are explained by cellular context and regulatory mechanisms.
  • It plays a role in cell fate regulation and can be targeted for cancer therapy.
  • The miR-17-92 cluster holds potential as a prognostic biomarker and therapeutic target in human cancers.
Keywords:
CancerMir-17–92 clusterMirnaOncogeneTumour suppressor

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