Related Experiment Video

Updated: Aug 23, 2025

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

15.8K

Increased uncoupling protein 1 levels are associated with attention deficit and hyperactivity disorder in

Mustafa Esad Tezcan1, Halit Necmi Uçar2, Hüsamettin Vatansev3

  • 1Department of Child and Adolescent Psychiatry, Konya City Hospital, Karatay, Konya, 42020, Turkey.

Journal of Psychiatric Research
|November 3, 2022
PubMed

Insights

Serum uncoupling protein 1 (UCP1) levels were significantly different in children with attention deficit and hyperactivity disorder (ADHD). This finding suggests UCP1 may be associated with childhood ADHD, unlike visfatin and irisin.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Neuroscience

Background:

  • Attention deficit and hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children.
  • Adipokines, such as visfatin, irisin, and uncoupling protein 1 (UCP1), are signaling molecules with potential roles in metabolic and inflammatory processes.
  • The relationship between adipokines and ADHD pathophysiology is not well understood.

Purpose of the Study:

  • To compare serum levels of visfatin, irisin, and UCP1 in children with ADHD and healthy controls.
  • To explore the association between these adipokines and cognitive function in children with ADHD, using the Stroop Color Test and Serial Digit Learning Test.

Main Methods:

  • A case-control study involving 45 medication-free children diagnosed with ADHD and 43 age- and gender-matched healthy controls (ages 8-12 years).
  • Serum samples were analyzed for visfatin, irisin, and UCP1 concentrations using enzyme-linked immunosorbent assay (ELISA).
  • Neuropsychological assessments included the Stroop Color Test and Serial Digit Learning Test.

Main Results:

  • Serum UCP1 levels were significantly higher in the ADHD group compared to the control group.
  • No statistically significant differences were observed in serum visfatin or irisin levels between the groups.
  • Adipokine levels did not show a significant correlation with performance on the neuropsychological tests, even after controlling for BMI, age, and gender.

Conclusions:

  • The study suggests a potential association between elevated UCP1 levels and ADHD in children.
  • Visfatin and irisin do not appear to be significantly linked to ADHD in this pediatric cohort.
  • Further research is warranted to elucidate the role of UCP1 in ADHD pathogenesis and its potential as a biomarker.
Abstract

Keywords:
Attention deficit hyperactivity disorderExecutive functionsIrisinUCP1Visfatin

More Related Videos

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

5.8K
Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol13:09

Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol

Published on: April 1, 2018

10.4K

Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
157
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
684
Modeling in Therapy01:26

Modeling in Therapy

Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
138
Drugs Affecting Neurotransmitter Release or Uptake01:21

Drugs Affecting Neurotransmitter Release or Uptake

Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.2K
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
278
Information Processing Approach01:30

Information Processing Approach

The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is...
103