Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural Basis for the Pro-amyloidogenic Action and Ligand Binding of a Novel W72R Variant of Human Apolipoprotein A-I.

Journal of molecular biology·2026
Same author

Prevalence and Burden of Cardiac Amyloidosis in a Population-Based Autopsy Cohort.

Circulation·2026
Same author

Unmasking the great masquerader with mass spectrometry.

Kidney international·2026
Same author

Semaphorin 3B-Membranous Nephropathy in Adults.

Kidney international reports·2026
Same author

Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits: An Immunologic Crossroads.

Glomerular diseases·2026
Same author

TNMD BRICHOS domain attenuates tau pathology and memory deficits in a mouse model of tauopathy.

Cell death & disease·2026

Related Experiment Video

Updated: Aug 23, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.6K

Light Chain-Only Immunotactoid Glomerulopathy: A Case Report.

Lihong Bu1, Vincent Javaugue2, Sophie Chauvet3

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|November 3, 2022
PubMed
Summary
This summary is machine-generated.

This study describes a rare form of immunotactoid glomerulopathy (ITG) caused by only kappa light chains in a multiple myeloma patient. The findings suggest a novel pathway involving complement activation by nephrotoxic light chains.

Keywords:
Alternative pathway of complementCase reportCast nephropathyDialysisImmunoglobulin depositsImmunotactoid glomerulopathy (ITG)Kappa light chainMonoclonal light chainProliferative glomerulonephritisRenal failure

More Related Videos

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
07:45

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

Published on: October 21, 2014

8.0K
Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
05:03

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges

Published on: April 26, 2024

768

Related Experiment Videos

Last Updated: Aug 23, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.6K
An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
07:45

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

Published on: October 21, 2014

8.0K
Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
05:03

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges

Published on: April 26, 2024

768

Area of Science:

  • Nephrology
  • Hematology
  • Immunology

Background:

  • Immunotactoid glomerulopathy (ITG) is a rare kidney disease often linked to lymphoproliferative disorders.
  • Typical ITG presents with glomerulonephritis and microtubular immunoglobulin G deposits.
  • A monotypic variant of ITG is characterized by monoclonal immunoglobulin deposits.

Observation:

  • A patient with high-risk kappa light chain multiple myeloma presented with acute kidney injury, hematuria, proteinuria, and hypocomplementemia.
  • Kidney biopsy showed immunotactoid glomerulopathy alongside kappa light chain myeloma cast nephropathy.
  • Glomerular deposits contained only kappa light chain and C3, with proteomic analysis confirming kappa light chain constant domain and IGKV3 subgroup.

Findings:

  • The study identified a light chain-only variant of immunotactoid glomerulopathy.
  • Glomerular deposits lacked heavy chains and lambda light chains.
  • Complement components (C3, C5, C6, C7, C9) were detected in glomeruli, suggesting complement system involvement.

Implications:

  • The pathogenesis of this light chain-only ITG may involve alternative complement pathway activation by nephrotoxic kappa light chains.
  • This finding expands the understanding of ITG pathogenesis and its association with multiple myeloma.
  • Further research into complement-targeted therapies for light chain-driven kidney diseases is warranted.