Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Real-Time, Objective Assessment of Facial Paralysis Using a Mobile Tool (FaceADE): Feasibility Case-Control Study.

JMIR formative research·2026

Same author

Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Genomic Contributors to Congenital Diaphragmatic Hernia: Results of Exome Sequencing in 560 Probands and Cross Reference of Findings in an Independent Cohort.

American journal of medical genetics. Part A·2026

Same author

Early Childhood Outcomes in Severe Congenital Diaphragmatic Hernia Treated with Fetoscopic Endoluminal Tracheal Occlusion (FETO) versus Non-FETO at a Single Center.

Fetal diagnosis and therapy·2026

Same author

Maternal Subcutaneous Seroma following Open Maternal Fetal Surgery for Closure of Fetal Open Neural Tube Defects.

Fetal diagnosis and therapy·2026

Same author

Wormian bones: expanded differential diagnosis and implications for abnormal head shape in infancy.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026

Search research articles

Related Experiment Video

Updated: Aug 23, 2025

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Published on: October 9, 2018

Molecular and Cellular In Utero Therapy.

Cara L Berkowitz¹, Valerie L Luks¹, Marcelina Puc¹

¹Division of Pediatric General, Thoracic and Fetal Surgery, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.

Clinics in Perinatology

|November 3, 2022

Summary

New in utero therapies offer hope for treating genetic disorders before birth. Advances in gene editing and cell therapies show promise, but further research is needed for safety and effectiveness.

Keywords:

In utero enzyme replacement therapy In utero gene editing In utero stem cell transplantation In utero therapy Maternal–fetal medicine

More Related Videos

A Mouse Model of in Utero Transplantation

A Mouse Model of in Utero Transplantation

Published on: January 27, 2011

Utero-tubal Embryo Transfer and Vasectomy in the Mouse Model

Utero-tubal Embryo Transfer and Vasectomy in the Mouse Model

Published on: February 28, 2014

Related Experiment Videos

Last Updated: Aug 23, 2025

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Published on: October 9, 2018

A Mouse Model of in Utero Transplantation

A Mouse Model of in Utero Transplantation

Published on: January 27, 2011

Utero-tubal Embryo Transfer and Vasectomy in the Mouse Model

Utero-tubal Embryo Transfer and Vasectomy in the Mouse Model

Published on: February 28, 2014

Area of Science:

Maternal-fetal medicine
Molecular and cellular therapeutics
Genetics

Background:

Advances in maternal-fetal medicine and gene sequencing enable novel in utero treatments.
Current postnatal strategies for single-gene disorders are often limited.
Fetal development offers a unique window for therapeutic intervention.

Purpose of the Study:

To explore the potential of in utero molecular and cellular therapeutics.
To address single-gene disorders with limited postnatal treatment options.
To leverage fetal developmental properties for early disease correction.

Main Methods:

Gene editing
Enzyme replacement therapy
Stem cell transplantation

Main Results:

Preclinical studies in animal models show encouraging results for in utero therapies.
These therapies aim to correct monogenic disorders before irreversible pathology develops.

Conclusions:

In utero therapies represent a promising new frontier for treating genetic diseases.
Further research on safety and efficacy is crucial before clinical application.