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Related Experiment Video

Updated: Aug 23, 2025

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
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Mindfulness Training Changes Brain Dynamics During Depressive Rumination: A Randomized Controlled Trial.

Anne Maj van der Velden1, Jacqueline Scholl2, Else-Marie Elmholdt3

  • 1Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Psychiatry, Oxford University and Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, United Kingdom.

Biological Psychiatry
|November 3, 2022
PubMed
Summary
This summary is machine-generated.

Mindfulness-based cognitive therapy reduced brain connectivity in the salience network during rumination in individuals with recurrent depression. This change improved attention control towards bodily sensations, offering a new understanding of depression treatment.

Keywords:
DepressionInteroceptive awarenessMechanismsMindfulnessNeural connectivityRumination

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Last Updated: Aug 23, 2025

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Behavioral Therapy

Background:

  • Depression is a major global health issue, with depressive rumination worsening its impact.
  • Mindfulness meditation enhances attention regulation and present-moment awareness, beneficial for managing ruminative thoughts.

Purpose of the Study:

  • To investigate the neurocognitive mechanisms of mindfulness-based cognitive therapy (MBCT) for recurrent depression.
  • To compare MBCT with treatment as usual (TAU) in modulating brain activity during induced rumination.

Main Methods:

  • A randomized controlled functional magnetic resonance imaging (fMRI) study with 80 participants (50 MBCT, 30 TAU).
  • Brain activity was measured during rest, mindfulness practice, and experimentally induced rumination.
  • The study examined the relationship between neurocognitive changes and dispositional psychological processes.

Main Results:

  • MBCT significantly decreased salience network connectivity to the lingual gyrus during rumination compared to TAU.
  • This modulation of brain connectivity mediated improvements in sustained and controlled attention to body sensations.

Conclusions:

  • Clinically effective mindfulness interventions can modulate neurocognitive functioning during depressive rumination.
  • MBCT enhances the ability to sustain attention to bodily sensations, offering a potential mechanism for reducing depressive symptoms.