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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Healthy aging and chronic kidney disease
Reshma Aziz Merchant1,2, Anantharaman Vathsala2,3
1Division of Geriatric Medicine, Department of Medicine, National University Hospital, Singapore, Singapore.
Kidney Research and Clinical Practice
|November 3, 2022
Summary
Chronic kidney disease (CKD) accelerates aging, frailty, and dementia, increasing mortality risk in older adults. Early screening for frailty, appetite loss, and cognitive issues in CKD patients is crucial for better health outcomes.
Area of Science:
- Gerontology
- Nephrology
- Public Health
Background:
- Global population aging leads to increased noncommunicable diseases like chronic kidney disease (CKD).
- Lifespan increases outpace health spans, with the last decade often marked by poor health.
- CKD is recognized as a model of accelerated aging, linked to physical and cognitive decline, frailty, and poor quality of life.
Purpose of the Study:
- To highlight the interconnectedness of CKD, frailty, and dementia in the aging population.
- To emphasize the role of CKD in accelerating aging-related conditions.
- To advocate for integrated healthcare strategies for older adults with CKD.
Main Methods:
- Review of the literature on aging, CKD, frailty, and dementia.
- Analysis of the synergistic relationship and shared risk factors between CKD, frailty, and dementia.
- Identification of key mechanisms through which CKD impacts aging and functional decline.
Main Results:
- CKD, dementia, and frailty share a triangular relationship with synergistic effects.
- CKD accelerates frailty and dementia via uremic toxicity, metabolic issues, malnutrition, and sleep disturbances.
- Frailty exacerbates CKD progression and significantly increases mortality risk.
Conclusions:
- Healthcare systems must implement CKD prevention for high-risk older adults.
- Screening for frailty, poor appetite, and cognitive impairment in CKD patients is essential.
- Person-centered interventions are needed to address factors contributing to poor outcomes in aging CKD patients.
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