Related Experiment Video
Updated: Aug 23, 2025
08:51
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
Published on: September 20, 2024
1.4K
Decoding the mechanism of hypertension through multiomics profiling
Eric Adua1,2
1School of Clinical Medicine, Medicine & Health, Rural Clinical Campus, University of New South Wales, Wagga Wagga, NSW, Australia. e.adua@unsw.edu.au.
Journal of Human Hypertension
|November 4, 2022
Summary
High blood pressure (hypertension) is a major cardiovascular risk. Multi-omics approaches analyzing genomics, transcriptomics, proteomics, glycomics, and lipidomics offer new insights for predicting and diagnosing hypertension.
Area of Science:
- Cardiovascular research
- Genomics and molecular biology
Background:
- Hypertension is a primary risk factor for cardiovascular events and mortality.
- High-throughput technologies enable whole-genome exploration, identifying hypertension-associated genes.
Purpose of the Study:
- To review the pathophysiology of hypertension.
- To highlight multi-omics approaches for hypertension prediction and diagnosis.
Main Methods:
- Genomic analysis using high-throughput technologies.
- Exploration of post-genomic biomarkers including transcriptomics, proteomics, glycomics, and lipidomics.
Main Results:
- Identification of dysregulated genes linked to hypertension.
- New insights into the molecular mechanisms of hypertension through multi-omics data.
Conclusions:
- Multi-omics strategies are crucial for advancing the prediction and diagnosis of hypertension.
- Understanding molecular underpinnings can lead to improved hypertension management.
Related Concept Videos
01:29Hypertension II: Pathophysiology
51
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
51
01:18Hypertension and Regulation of Blood Pressure
2.2K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.2K
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
39
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
39
01:28Hypertension I: Introduction
49
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
49
01:18Neural Regulation of Blood Pressure
3.2K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
3.2K
01:17Hormonal Regulation of Blood Pressure
3.0K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
3.0K