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Related Concept Videos

Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
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Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
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Overview of Cell Death01:30

Overview of Cell Death

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Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
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Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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Apoptosis01:30

Apoptosis

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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
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Autophagic Cell Death01:18

Autophagic Cell Death

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Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
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Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Updated: Aug 23, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

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Ferroptosis assassinates tumor.

Tao Luo1, Yile Wang1, Jinke Wang2

  • 1State Key Laboratory of Bioelectronics, Southeast University, 210096, Nanjing, China.

Journal of Nanobiotechnology
|November 4, 2022
PubMed
Summary
This summary is machine-generated.

A novel cancer therapy, Ferroptosis ASsassinates Tumor (FAST), combines iron oxide nanoparticles with gene knockdown to target cancer cells. This innovative approach shows significant anti-tumor activity and safety in preclinical models, offering a new therapeutic strategy.

Keywords:
Adeno-associated virusFerroptosisNF-κBiron oxide nanoparticlesmicroRNA

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Area of Science:

  • Nanomedicine
  • Oncology
  • Biotechnology

Background:

  • Cancer remains a significant global health threat, necessitating novel therapeutic strategies.
  • Existing treatments face challenges, driving the urgent demand for innovative cancer therapies.
  • Ferroptosis, a regulated form of cell death, presents a promising target for cancer treatment.

Purpose of the Study:

  • To develop and evaluate a novel cancer therapy, Ferroptosis ASsassinates Tumor (FAST), for enhanced anti-tumor efficacy.
  • To investigate the efficacy and safety of FAST in various cancer models.
  • To establish FAST as a new class of advanced combinatorial nanomaterials for cancer treatment.

Main Methods:

  • FAST therapy was developed by combining iron oxide nanoparticles with cancer-selective knockdown of seven key ferroptosis-resistant genes (FPN, LCN2, FTH1, FSP1, GPX4, SLC7A11, NRF2).
  • The anti-tumor activity and specificity of FAST were assessed in vitro using various cancer cell lines and in vivo using mouse models of leukemia, colon cancer, lung metastatic melanoma, and spontaneous breast cancer.
  • The survival rates and tumor relapse were monitored in treated mice.

Main Results:

  • FAST demonstrated notable anti-tumor activity against a variety of cancer cells with minimal impact on normal cells.
  • FAST successfully eradicated established tumors in over 50% of mice across leukemia, colon cancer, and lung metastatic melanoma models, significantly improving survival up to 250 days without relapse.
  • FAST inhibited spontaneous breast cancer growth and improved survival in mice, showcasing high pan-anti-tumor efficacy, cancer specificity, and in vivo safety.

Conclusions:

  • FAST represents a novel and effective cancer therapy with broad applicability and high specificity.
  • The development of FAST establishes a new category of advanced combinatorial nanomaterials, merging chemical and biochemical components.
  • FAST therapy holds significant promise as an innovative and safe treatment for various cancers, potentially revolutionizing cancer treatment approaches.