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[Application of low-dose esmolamine in general anesthesia in pediatric surgeries]
1Department of Anesthesiology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen 361000, China.
Insights
Continuous low-dose esmolamine infusion in pediatric surgery reduces intraoperative opioid needs and postoperative pain. This method effectively manages pain without negatively impacting the quality of patient awakening.
Area of Science:
- Anesthesiology
- Pediatric Surgery
- Pharmacology
Background:
- General anesthesia in pediatric surgery often requires significant opioid administration.
- Postoperative pain management is crucial for patient recovery and outcomes.
Purpose of the Study:
- To investigate the impact of continuous low-dose esmolamine infusion on intraoperative opioid requirements.
- To assess the effect of esmolamine on awakening quality and postoperative pain in children undergoing surgery.
Main Methods:
- 100 children (6-8 years) were randomized into esmolamine or saline groups.
- Esmolamine was administered pre-induction and as a continuous infusion.
- Opioid dosage, recovery times, and postoperative pain scores (VAS) were recorded.
Main Results:
- The esmolamine group required significantly less remifentanil intraoperatively.
- Postoperative pain scores (VAS) were lower in the esmolamine group.
- No significant differences were observed in respiratory or consciousness recovery times.
Conclusions:
- Continuous low-dose esmolamine infusion effectively reduces intraoperative opioid use in pediatric surgery.
- Esmolamine improves postoperative pain control without compromising awakening quality.
- This strategy offers a promising approach for enhanced recovery after pediatric surgery.
Objective:
To explore the effect of continuous low-dose infusion of esmolamine on intraoperative dosage of opioids and awakening quality in general anesthesia in pediatric surgeries.
Methods:
A total of 100 children (6-8 years of age) undergoing pediatric surgery under general anesthesia were randomized equally into observation group and control group.In the observation group, the children received an intravenous injection of 0.1mg/kg esmolamine 10 min before induction of general anesthesia, followed by intravenous infusion of esmolamine at 2 μg•kg-1•min-1 until the end of the operation; those in the control group were infused with the same volume of normal saline instead of esmolamine in the same manner.The dosage of remifentanil during operation, recovery time of spontaneous breathing, recovery time of consciousness and extubation time were recorded in all the cases.The VAS score at 15, 30 and 60 min after extubation were assessed, and intravenous injection of naborphine 0.3 mg/kg was given for a VAS score ≥4;the total dosage of naborphine and adverse events were recorded for all the patients.
Results:
The total dose of remifentanil was significantly lower in the observation group than in the control group, but the spontaneous respiratory recovery time, consciousness recovery time and extubation time did not differ significantly between the two groups.The VAS scores at 15, 30 and 60 min after extubation were all better in the observation group than in the control group; the total intraoperative dose of naborphine was significantly lower in the observation group.
Conclusion:
Continuous infusion of low-dose esmolamine during pediatric surgery can effectively lower intraoperative dosage of opioids and reduce pain during recovery without affecting the quality of awakening.
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