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Prekallikrein deficiency in a dog
Journal of the American Veterinary Medical Association
|January 1, 1986
Summary
A dog with chronic hematuria had prolonged clotting times due to prekallikrein deficiency. This rare bleeding disorder was unrelated to the dog
Area of Science:
- Veterinary Medicine
- Hematology
- Canine Coagulation
Background:
- Prekallikrein deficiency is a rare inherited coagulopathy.
- It typically presents with mild or no bleeding symptoms.
- The intrinsic clotting pathway is affected.
Observation:
- A 15-year-old male dog presented with chronic hematuria.
- Coagulation assays revealed a prolonged activated partial thromboplastin time.
- Plasma analysis identified a prekallikrein deficiency.
Findings:
- The dog's hematuria was attributed to a renal transitional cell carcinoma.
- The prekallikrein deficiency did not appear to cause or exacerbate the hematuria.
- This case highlights a rare canine bleeding disorder in the context of a malignancy.
Implications:
- Prekallikrein deficiency in dogs may be asymptomatic or subclinical.
- Neoplasia can be the primary cause of bleeding in dogs with underlying coagulopathies.
- Further research into canine prekallikrein deficiency is warranted.