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Published on: June 16, 2014
Factors Affecting Neurocognitive Function in Children with Chronic Kidney Disease: A Systematic Review
Elrika A Wijaya1, Purboyo Solek1, Dzulfikar D L Hakim1
1Department of Child Health, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Insights
Chronic kidney disease (CKD) in children can impact neurocognitive function. Maternal education and kidney transplant positively influence outcomes, while longer hemodialysis duration is linked to poorer neurocognitive function.
Area of Science:
- Pediatric Nephrology
- Neurodevelopmental Disorders
- Quality of Life Studies
Background:
- Chronic kidney disease (CKD) in children is associated with impaired neurocognitive function.
- This impairment significantly affects the overall quality of life for affected children.
Purpose of the Study:
- To identify factors influencing neurocognitive function in pediatric CKD patients.
- To examine treatment modalities that may impact neurocognitive outcomes in this population.
Main Methods:
- A systematic review of literature published between 2011-2021 was conducted.
- The review adhered to PRISMA guidelines and included studies on children aged 0-18 with CKD.
- Data were extracted from three electronic databases: PubMed, ScienceDirect, and SpringerLink.
Main Results:
- Maternal education was identified as a significant factor affecting neurocognitive function.
- Children with CKD who received a kidney transplant generally showed better neurocognitive outcomes.
- Longer hemodialysis (HD) duration correlated with poorer neurocognitive outcomes, alongside factors like depression, abnormal birth history, seizures, and hypertension.
Conclusions:
- CKD in children can lead to neurocognitive dysfunction through complex mechanisms.
- Further research is required to elucidate these mechanisms and develop effective prevention strategies.
- Optimizing therapeutic modalities is crucial for improving both renal and neurocognitive function in pediatric CKD.
Purpose:
In children, chronic kidney disease (CKD) has been known to affect neurocognitive function which can impair the quality of life. This study aims to determine the factors and treatment modalities which might affect neurocognitive function in pediatric population with CKD.
Patients And Methods:
A systematic review was done using 3 electronic databases: PubMed, ScienceDirect, SpringerLink, and carried out based on PRISMA guidelines. Our review included articles published in the last 10 years (2011-2021) in English, on children aged 0-18 years with CKD. Factors affecting the children's neurocognitive function were assessed.
Results:
Eight articles were included in this study. Three articles reported that parent's education, especially maternal education affect the neurocognitive function of children with CKD. In relation with modalities, in general, children with CKD who had kidney transplant had a better neurocognitive outcome. A longer duration of hemodialysis (HD) was associated with poorer neurocognitive outcomes. Other factors that can affect the neurocognitive function included depression, a history of abnormal births, seizures, and hypertension.
Conclusion:
In children, CKD might cause neurocognitive function disorders through various complex and interconnected mechanisms. Further studies are needed to determine the mechanism and prevention of neurocognitive disorders, as well as the best choice of therapeutic modality to improve both kidney function and neurocognitive function in children with CKD.
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