Research progress on the relationship between mitochondrial function and heart failure: A bibliometric study from...

Area of Science:

• Cardiology
• Mitochondrial Biology
• Bibliometrics

Background:

• Heart failure (HF) is a significant global public health concern.
• The intricate relationship between mitochondrial function and HF is gaining increasing research attention.
• A substantial body of literature has emerged over the past two decades exploring this connection.

Purpose of the Study:

• To conduct a bibliometric analysis of research on mitochondrial function (MF) and heart failure (HF) over the last 20 years.
• To identify trends, leading countries, institutions, authors, and journals in this research area.
• To map the key research focuses and future directions in the field.

Main Methods:

• Bibliometric analysis utilizing Microsoft Excel 2019, a bibliometric analysis platform, WoSCC database, VosViewer, and Citespace.
• Analysis of publication trends, country/institution/author productivity, and journal impact.
• Identification of core research themes through keyword and citation analysis.

Main Results:

• A consistent year-on-year increase in publications was observed.
• China and the United States lead in research output and international collaboration.
• The University of California system is a highly impactful research institution, and Yip H.K. is a prolific author.
• The American Journal of Physiology-heart and Circulatory Physiology is a prominent journal in this field.
• Key research themes include oxidative stress, metabolic dysfunction, mitochondrial calcium homeostasis, quality control, and inflammation in HF pathogenesis.

Conclusions:

• Research on mitochondria and heart failure is expanding rapidly, with significant contributions from China and the US.
• Current research highlights critical roles of mitochondrial dysfunction in HF.
• Future research and therapeutic strategies will likely focus on targeted mitochondrial regulation for HF prevention and treatment.