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Case report: Going through pregnancy safely after twice partial nephrectomy for bilateral kidneys with
Kunhan Dai1, Wencheng Jiang1, Siyu Chen1
1Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in Oncology
|November 4, 2022
Summary
Hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinoma (HLRCC-RCC) is rare. This case presents a successful pregnancy after bilateral partial nephrectomy for HLRCC-RCC, with nivolumab showing potential for preventing recurrence.
Area of Science:
- Oncology
- Genetics
- Nephrology
Background:
- Hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinoma (HLRCC-RCC) is a rare genetic kidney cancer linked to fumarate hydratase (FH) gene mutations.
- Bilateral HLRCC-RCC is exceptionally rare, with no prior reports of successful pregnancy following bilateral partial nephrectomy.
Observation:
- A 25-year-old woman presented with bilateral renal tumors.
- She underwent two partial nephrectomies (left robot-assisted, right laparoscopic) for HLRCC-RCC confirmed by genetic testing (FH gene mutation).
Findings:
- The patient successfully conceived and delivered a baby 38 months post-surgery.
- Adjuvant therapy with interferon and nivolumab was administered to prevent recurrence.
- No tumor progression was observed during the follow-up period.
Implications:
- This case provides a reference for managing pregnancy in patients with bilateral HLRCC-RCC undergoing partial nephrectomy.
- Nivolumab may be an effective strategy for preventing tumor recurrence in HLRCC-RCC patients.
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