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Low-dose Aspirin may Prevent Preeclampsia by Inhibiting the Expression of ATF2
Sha Xiao1, Lu Guo1, Ming Zhang1
1Department of Obstetrics and Gynecology, Tianjin First Center Hospital, Tianjin 300192, China.
Aims:
To explore the ATF2 expression of preeclampsia patients and investigate whether the level of ATF2 expression impacted the low-dose aspirin treatment of preeclampsia patients.
Background:
Preeclampsia is a severe pregnancy-related hypertension disorder and refers to hypertension.
Objective:
This study was designed to explore the activating transcription factor 2 (ATF2) expression of preeclampsia patients and investigate whether the level of ATF2 expression impacted the low-dose aspirin treatment of preeclampsia patients.
Methods:
Firstly, we collected the plasma of normal and preeclampsia pregnancies and quantified the expressions of ATF2 by ELISA. Then we quantified the expression of the three downstream target genes of ATF2 (IL-8, IL-6 and MMP-2). Finally, we collected and quantified the interventional and observational group plasma. All data were compared by t-test (p<0.05).
Results:
ATF2 and its target genes (IL-6, IL-8 and MMP-2) were upregulated in preeclampsia patients. In addition, ATF2 and its target genes were downregulated in the interventional group (LDA-treated group).
Conclusion:
Our results indicated that LDA could inhibit ATF2 expression in preeclampsia. It suggests that ATF2 may be a potential target of LDA in the prevention of preeclampsia.
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