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Oligosaccharide Assembly

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...

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Related Experiment Video

Updated: Aug 23, 2025

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

Published on: July 6, 2012

Fluorine-Directed Automated Mannoside Assembly.

Charlotte S Teschers¹, Ryan Gilmour¹

¹Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstr. 36, 48149, Münster, Germany.

Angewandte Chemie (International Ed. in English)

|November 4, 2022

Summary

This summary is machine-generated.

Fluorine-directed automated glycan assembly (FDAGA) enables stereocontrolled synthesis of fluorinated carbohydrates on solid support. This novel strategy simplifies the creation of complex, site-modified glycomimetics for drug discovery.

Failed At:

2026-06-19T13:39:49.035911+00:00

Keywords:

Automated Glycan Assembly Carbohydrates Fluorination Oligomannose Stereoselective Synthesis

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