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Updated: Aug 23, 2025

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Has low-dose intracoronary thrombolysis gained ground in primary percutaneous intervention?
Rasha Kaddoura1, Mohamed Izham Mohamed Ibrahim2, Abdul Rahman Arabi3
1Pharmacy Department, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
Insights
Low-dose intracoronary thrombolytic agents may improve outcomes for ST-segment elevation myocardial infarction patients. This review examines meta-analyses of intracoronary thrombolysis during primary percutaneous intervention for high thrombus burden.
Area of Science:
- Cardiology
- Interventional Cardiology
- Pharmacology
Background:
- Reducing thrombus burden is crucial for improving patient outcomes in ST-segment elevation myocardial infarction (STEMI).
- High thrombus burden in STEMI is associated with poorer prognosis and complications.
- Current treatment strategies aim to restore coronary blood flow rapidly.
Abstract:
Reducing thrombus burden would improve patient's outcomes. Low-dose intracoronary thrombolytic agent administration has been considered to improve myocardial microcirculation, cardiac function, and major adverse cardiovascular events in patients presenting with ST-segment elevation myocardial infarction and high thrombus burden. This paper discusses published meta-analyses on intracoronary thrombolysis in primary percutaneous intervention.
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