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Related Concept Videos

Proteomics01:33

Proteomics

7.7K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.7K

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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Schistosome proteomics: updates and clinical implications.

William Castro-Borges1, R Alan Wilson2

  • 1Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Brasil.

Expert Review of Proteomics
|November 4, 2022
PubMed
Summary

Schistosome proteomics offers insights into parasite biology and disease. Careful interpretation of proteomic data is crucial for understanding schistosome immune evasion, vaccine development, and disease pathogenesis.

Keywords:
Diagnosticsalimentary tractdisintegromeleakyomepathogenesisproteomicssecretometegumentvaccine

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Area of Science:

  • Parasitology
  • Molecular Biology
  • Immunology

Background:

  • Schistosomes are complex helminth parasites that cause schistosomiasis.
  • Their biology involves intricate host invasion, maturation, reproduction, and immune evasion strategies.
  • Understanding schistosome proteomes is challenging due to their complex body plan.

Purpose of the Study:

  • To review proteomic findings related to schistosome biology.
  • To focus on host-parasite interfaces and secretions.
  • To introduce novel concepts for data interpretation and highlight clinical implications.

Main Methods:

  • Proteomic analysis of schistosomes.
  • Focus on tegument, alimentary tract, cercaria secretions, schistosomulum, and eggs.
  • Application of "leakyome" and "disintegrome" concepts for data interpretation.

Main Results:

  • Proteomics has advanced understanding of schistosome biology and pathogenesis.
  • Identified potential vaccine candidates.
  • Highlighted the need for careful data interpretation in light of eukaryotic cell biology.

Conclusions:

  • Proteomic data provides valuable insights into schistosome biology and pathogenesis.
  • Novel concepts like "leakyome" and "disintegrome" aid interpretation.
  • Findings have implications for vaccine design, diagnostics, and understanding schistosomiasis.