Early neural potentiation to centrally and peripherally presented fear-conditioned faces

For humans, it is vitally important to rapidly detect and process threatening signals regardless of whether stimuli occur at fixation or in the periphery. However, it is unknown whether eccentricity affects early neuronal electrophysiological responses to fear-conditioned stimuli. We examined early event-related potentials (ERPs) of the electroencephalogram (EEG) to fear-conditioned faces to address this question. Participants (N = 80) were presented with faces, either paired with an aversive (CS+) or neutral sound (CS-), at central or peripheral positions. We ensured constant central fixation using online eye-tracking but directed attention to either centrally or peripherally presented faces. Manipulation checks showed successful fear-conditioning (i.e., on average lower ratings in valence and higher ratings in arousal and perceived threat) and successful shifts of visuospatial attention indexed by high task performance and pre-stimulus alpha lateralization of the EEG spectra. We observed a generally increased P1 to fear-conditioned faces regardless of presentation location. An N170 difference between fear-conditioned and neutral stimuli was found but was restricted to the central location and depended on the effectivity of fear-conditioning. A similar effect was observed for the early posterior negativity (EPN). Trait anxiety was not related to differential ERP responses to CS+ versus CS- faces for any ERP component. These findings suggest that the P1 indexes early responses to centrally and peripherally presented fear-conditioned faces. Subsequent stages are modulated by the spatial location of the stimuli. This suggests different stages of neural processing of fear-conditioned faces depending on their spatial location. Finally, our results question the hypothesis that trait anxiety in healthy participants is related to altered visual processing of fear-conditioned faces.