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Updated: Aug 23, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Imine Directed Cp*RhIII -Catalyzed N-H Functionalization and Annulation with Amino Amides, Aldehydes, and Diazo
Adam J Zoll1, Jenna C Molas1, Brandon Q Mercado1
1Department of Chemistry, Yale University, 225 Prospect St., New Haven, CT 06520, USA.
Abstract:
A multicomponent annulation that proceeds by imine directed Cp*RhIII -catalyzed N-H functionalization is disclosed. The transformation affords piperazinones displaying a range of functionality and is the first example of transition metal-catalyzed multicomponent N-H functionalization. A broad range of readily available α-amino amides, including those derived from glycine, α-substituted, and α,α-disubstituted amino acids, were effective inputs and enabled the incorporation of a variety of amino acid side chains with minimal racemization. Branched and unbranched alkyl aldehydes and various stabilized diazo compounds were also efficient reactants. The piperazinone products were further modified through efficient transformations. Mechanistic studies, including X-ray crystallographic characterization of a catalytically competent five-membered rhodacycle with imine and amide nitrogen chelation, provide support for the proposed mechanism.
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