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Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
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Neutrophils as immune effector cells in antibody therapy in cancer

Leonie M Behrens1,2,3, Marjolein van Egmond1,2,3,4, Timo K van den Berg5

  • 1Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Vrije Universiteit Amsterdam, HV, Amsterdam, The Netherlands.

Immunological Reviews
|November 4, 2022
PubMed

Insights

Neutrophils, abundant immune cells, kill antibody-coated cancer cells via antibody-dependent cellular cytotoxicity (ADCC). This review details neutrophil mechanisms in cancer cell killing and their role in regulating anti-cancer immunity.

Area of Science:

  • Immunology
  • Oncology

Background:

  • Tumor-targeting monoclonal antibodies are crucial in cancer therapy.
  • Immune-mediated mechanisms, including ADCC, contribute to antibody efficacy.
  • Neutrophils are key effector cells in ADCC against antibody-opsonized tumor cells.

Purpose of the Study:

  • To review recent insights into neutrophil-mediated killing of antibody-opsonized cancer cells.
  • To explore the mechanisms by which neutrophils engage and eliminate cancer cells.
  • To discuss the broader role of neutrophils in regulating anti-cancer immunity.

Main Methods:

  • Review of existing literature on neutrophil function in cancer.
  • Analysis of mechanisms of antibody-dependent cellular cytotoxicity (ADCC).
  • Investigation of neutrophil interactions with antibody-opsonized tumor cells.

Main Results:

  • Neutrophils effectively kill antibody-opsonized cancer cells through Fc receptor engagement.
  • Mechanisms of neutrophil-mediated tumor cell lysis are increasingly understood.
  • Neutrophils influence adaptive anti-cancer immune responses.

Conclusions:

  • Neutrophils are potent mediators of anti-cancer immunity via ADCC.
  • Understanding neutrophil mechanisms can enhance antibody-based cancer therapies.
  • Neutrophils play a multifaceted role in cancer progression and immune regulation.
Keywords:
PMNcancerimmunotherapyneutrophilstrogocytosistrogoptosis

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