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Updated: Aug 23, 2025

A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl
Published on: November 28, 2014
Granzyme B: A novel therapeutic target for treatment of atopic dermatitis
Qian Zhang1, Qian Wang1, Li-Xia Zhang2
1School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Abstract:
Granzyme B is a serine protease that can play multiple roles in intracellular and extracellular perforin-dependent or non-perforin-dependent mechanisms. Granzyme B has been found to be an important factor involved in the pathogenesis of atopic dermatitis and is increased in both skin lesions and peripheral blood of atopic dermatitis patients. In this article, we review the correlation between granzyme B and atopic dermatitis to provide a novel therapeutic targeting option for clinical treatment of the latter.
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