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Process intensification in continuous flow biocatalysis by up and downstream processing strategies.

Lars-Erik Meyer¹, Markus Hobisch¹, Selin Kara²

¹Biocatalysis and Bioprocessing Group, Department of Biological and Chemical Engineering, Aarhus University, Gustav Wieds Vej 10, 8000 Aarhus, Denmark.

Current Opinion in Biotechnology

|November 4, 2022

Summary

This review explores continuous enzymatic production, highlighting process intensification through upstream enzyme immobilization and downstream processing in flow biocatalysis. It covers liquid-liquid extraction, adsorption, and crystallization for enhanced bioprocesses.

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Area of Science:

Biocatalysis
Chemical Engineering
Process Intensification

Background:

Continuous enzymatic production offers advantages over batch processes.
Process intensification is key to improving efficiency in biocatalysis.
Flow biocatalysis enables integrated upstream and downstream operations.

Purpose of the Study:

To review holistic continuous enzymatic production.
To emphasize process intensification in flow biocatalysis.
To provide an overview of upstream and downstream processing strategies.

Main Methods:

Enzyme immobilization techniques for upstream processing.
Continuous downstream processing unit operations: liquid-liquid extraction, adsorption, crystallization, and precipitation.

Main Results:

Enzyme immobilization is crucial for upstream flow biocatalysis.
Continuous downstream processing methods enhance overall efficiency.
Integrated upstream and downstream approaches are vital for holistic production.

Conclusions:

Continuous flow biocatalysis with intensified upstream and downstream processing is a promising area.
Further research into future trends will drive innovation in enzymatic production.