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Candidal suppurative peripheral thrombophlebitis: recognition, prevention, and management

T J Walsh, C I Bustamente, D Vlahov

    Infection Control : IC
    |January 1, 1986
    PubMed

    Insights

    Candida species can cause suppurative peripheral thrombophlebitis, a rare infection. Early diagnosis and combined surgical and antifungal treatment are crucial for managing this nosocomial fungal infection.

    Area of Science:

    • Medical Mycology
    • Infectious Diseases
    • Hospital Epidemiology

    Background:

    • Suppurative peripheral thrombophlebitis is rarely attributed to Candida species.
    • Nosocomial fungal infections pose significant challenges in acute-care settings.

    Purpose of the Study:

    • To investigate the occurrence and characteristics of candidal suppurative peripheral thrombophlebitis.
    • To identify risk factors and evaluate treatment strategies for this rare fungal infection.

    Main Methods:

    • Retrospective analysis of seven patients diagnosed with candidal suppurative peripheral thrombophlebitis over 15 months.
    • Clinical data collection including symptoms, laboratory results, preceding infections, antibiotic exposure, and treatment outcomes.

    Main Results:

    • Seven patients developed candidal suppurative peripheral thrombophlebitis, presenting with fever and tender palpable cords.
    • Candida species were isolated from resected veins or pus; four patients had candidemia.
    • Risk factors included prolonged broad-spectrum antibiotic use, preceding bacterial infections, and deficient catheter care.

    Conclusions:

    • Candida species should be considered in cases of suppurative peripheral thrombophlebitis, especially in hospitalized patients.
    • Combined segmental venous resection and intravenous amphotericin B is a recommended therapeutic approach.
    • Improved catheter care and judicious antibiotic use are essential for preventing such nosocomial infections.

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